In the area of Quality of Experience (QoE), one challenge is to design test methodologies in order to evaluate the perceived quality of multimedia content delivered through technical sys-tems. Traditionally, this evaluation is done using subjective opinion tests. However, sometimes it is difficult for observers to communicate the experienced quality through the given scale. Fur-thermore. those tests do not give insights into how the user is reacting on an internal physiological level. To overcome these issues, one approach is to use physiological measures, in order to derive a direct non-verbal response of the recipient. In this paper, we review studies that have been performed in the domain of QoE using physiological measures and we look into current activities in standardization bodies. We present challenges this research faces. and give an overview on what researchers should be aware of when they want to start working in this research area.