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Simulations of 3D bioprinting: Predicting bioprintability of nanofibrillar inks
Fraunhofer-Chalmers Centre, Sweden.
Wallenberg Wood Science Center, Sweden ; Chalmers University of Technology, Sweden.
Fraunhofer-Chalmers Centre, Sweden.
RISE - Research Institutes of Sweden, Bioeconomy, Biorefinery and Energy. Wallenberg Wood Science Center, Sweden ; Chalmers University of Technology, Sweden.ORCID iD: 0000-0002-4919-1771
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2018 (English)In: Biofabrication, ISSN 1758-5082, E-ISSN 1758-5090, Vol. 10, no 3, article id 034105Article in journal (Refereed) Published
Abstract [en]

3D bioprinting with cell containing bioinks show great promise in the biofabrication of patient specific tissue constructs. To fulfil the multiple requirements of a bioink, a wide range of materials and bioink composition are being developed and evaluated with regard to cell viability, mechanical performance and printability. It is essential that the printability and printing fidelity is not neglected since failure in printing the targeted architecture may be catastrophic for the survival of the cells and consequently the function of the printed tissue. However, experimental evaluation of bioinks printability is time-consuming and must be kept at a minimum, especially when 3D bioprinting with cells that are valuable and costly. This paper demonstrates how experimental evaluation could be complemented with computer based simulations to evaluate newly developed bioinks. Here, a computational fluid dynamics simulation tool was used to study the influence of different printing parameters and evaluate the predictability of the printing process. Based on data from oscillation frequency measurements of the evaluated bioinks, a full stress rheology model was used, where the viscoelastic behaviour of the material was captured. Simulation of the 3D bioprinting process is a powerful tool and will help in reducing the time and cost in the development and evaluation of bioinks. Moreover, it gives the opportunity to isolate parameters such as printing speed, nozzle height, flow rate and printing path to study their influence on the printing fidelity and the viscoelastic stresses within the bioink. The ability to study these features more extensively by simulating the printing process will result in a better understanding of what influences the viability of cells in 3D bioprinted tissue constructs.

Place, publisher, year, edition, pages
2018. Vol. 10, no 3, article id 034105
Keywords [en]
3D bioprinting, bioink, cellulose nanofibrils, printability, simulation, 3D printers, Cells, Computational fluid dynamics, Cytology, Printing presses, Tissue, Viscoelasticity, Bioprinting, Tissue engineering
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-34419DOI: 10.1088/1758-5090/aac872Scopus ID: 2-s2.0-85049854410OAI: oai:DiVA.org:ri-34419DiVA, id: diva2:1237183
Note

 Funding details: WWSC, Wallenberg Wood Science Center; Funding details: 17-532; Funding details: Knut och Alice Wallenbergs Stiftelse;

 ÅForsk (Ångpanneföreningen’s Foundation for Research and Development) research grant 17-532: ‘Innovative Tool for Simulation of Nanocellulose Suspensions’.

Available from: 2018-08-07 Created: 2018-08-07 Last updated: 2018-08-22Bibliographically approved

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Håkansson, Karl

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