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Interactions between model cell membranes and the neuroactive drug propofol.
RISE - Research Institutes of Sweden, Bioscience and Materials, Surface, Process and Formulation.ORCID iD: 0000-0003-0195-3850
RISE - Research Institutes of Sweden, Bioscience and Materials, Surface, Process and Formulation.
RISE - Research Institutes of Sweden, Bioscience and Materials, Surface, Process and Formulation. KTH Royal Institute of Technology, Sweden.ORCID iD: 0000-0002-6394-6990
RISE - Research Institutes of Sweden, Bioscience and Materials, Surface, Process and Formulation. KTH Royal Institute of Technology, Sweden.
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2018 (English)In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 526, p. 230-243Article in journal (Refereed) Published
Abstract [en]

phospholipid, NR data reveal that propofol is located exclusively in the head group region, which is rationalized in the context of previous studies. The results imply a non-homogeneous distribution of propofol in the plane of real cell membranes, which is an inference that requires urgent testing and may help to explain why such low concentration of the drug are required to induce general anaesthesia.

Place, publisher, year, edition, pages
2018. Vol. 526, p. 230-243
Keywords [en]
Langmuir trough, Model membrane, Neutron reflectometry, Phospholipid monolayers, Propofol, Small amphiphilic drug, Surface pressure isotherm, Vibrational sum frequency spectroscopy
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Natural Sciences
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URN: urn:nbn:se:ri:diva-33920DOI: 10.1016/j.jcis.2018.03.052PubMedID: 29734090OAI: oai:DiVA.org:ri-33920DiVA, id: diva2:1214593
Available from: 2018-06-07 Created: 2018-06-07 Last updated: 2018-06-07Bibliographically approved

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Niga, PetruSwerin, Agne

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