Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Design and Biological Evaluation of Antifouling Dihydrostilbene Oxime Hybrids
UiT The Arctic University of Norway, Norway ; Umeå University, Sweden.
University of Gothenburg, Sweden.
Université de Bretagne Occidentale, France.
UiT The Arctic University of Norway, Norway.
Show others and affiliations
2018 (English)In: Marine Biotechnology, ISSN 1436-2228, E-ISSN 1436-2236Article in journal (Refereed) In press
Abstract [en]

By combining the recently reported repelling natural dihydrostilbene scaffold with an oxime moiety found in many marine antifoulants, a library of nine antifouling hybrid compounds was developed and biologically evaluated. The prepared compounds were shown to display a low antifouling effect against marine bacteria but a high potency against the attachment and growth of microalgae down to MIC values of 0.01 μg/mL for the most potent hybrid. The mode of action can be characterized as repelling via a reversible non-toxic biostatic mechanism. Barnacle cyprid larval settlement was also inhibited at low μg/mL concentrations with low levels or no toxicity observed. Several of the prepared compounds performed better than many reported antifouling marine natural products. While several of the prepared compounds are highly active as antifoulants, no apparent synergy is observed by incorporating the oxime functionality into the dihydrostilbene scaffold. This observation is discussed in light of recently reported literature data on related marine natural antifoulants and antifouling hybrids as a potentially general strategy for generation of improved antifoulants. 

Place, publisher, year, edition, pages
2018.
Keywords [en]
Antifouling, Batatasin, Dihydrostilbene, Hybrid, Ianthelline, Oxime
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-33508DOI: 10.1007/s10126-018-9802-zScopus ID: 2-s2.0-85043472294OAI: oai:DiVA.org:ri-33508DiVA, id: diva2:1192844
Available from: 2018-03-23 Created: 2018-03-23 Last updated: 2018-03-23Bibliographically approved

Open Access in DiVA

fulltext(873 kB)22 downloads
File information
File name FULLTEXT01.pdfFile size 873 kBChecksum SHA-512
2ce8d1b01167616b710a0f1cd3fee43066178e0c5fcc16c80f6d18122b5333dfa45be45ddc15e123023147bcc089658629ac423a682911991719b0b9b50fa2a6
Type fulltextMimetype application/pdf

Other links

Publisher's full textScopus

Authority records BETA

Svenson, Johan

Search in DiVA

By author/editor
Svenson, Johan
By organisation
Chemistry and Materials
In the same journal
Marine Biotechnology
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 22 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 15 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
v. 2.35.2