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New insights on the influence of manufacturing conditions and molecular weight on phase-separated films intended for controlled release
RISE - Research Institutes of Sweden, Bioscience and Materials, Agrifood and Bioscience. Chalmers University of Technology, Sweden.
Chalmers University of Technology, Sweden ; AstraZeneca R&D Gothenburg, Sweden.
Chalmers University of Technology, Sweden.
Chalmers University of Technology, Sweden ; AstraZeneca R&D Gothenburg, Sweden.
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2018 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 536, no 1, p. 261-271Article in journal (Refereed) Published
Abstract [en]

The aim of this work was to investigate how manufacturing conditions influence phase-separated films of ethyl cellulose (EC) and hydroxypropyl cellulose (HPC) with different molecular weights of HPC. Two HPC grades, SSL and M, with weight average molecular weights (Mw) of 30 × 103 g/mol and 365 × 103 g/mol, respectively, were combined with EC 10 cps (70:30 w/w EC/HPC) and spray-coated from ethanol solutions onto a rotating drum under well-controlled process conditions. Generally, a low spray rate resulted in a more rapid film drying process and, consequently, in smaller HPC-rich domains in the phase-separated film structure. For EC/HPC films with the low Mw HPC (SSL) the most rapid drying process resulted in a shift from a HPC-discontinuous to a partly bicontinuous structure and an increase in the permeability for water. In contrast, films containing the high Mw HPC (M) all showed bicontinuous structures, which resulted in overall higher water permeabilities and polymer release compared to the low Mw films. Interestingly, a maximum in permeability was observed for the high Mw films at intermediate spray rates. Below this spray rate the permeability decreased due to a lower amount of polymer released and at higher spray rates, the permeability decreased due to a loss of pore connectivity (or increased tortuosity). To conclude, this study shows that different Mw systems of EC/HPC can respond differently to variations in manufacturing conditions.

Place, publisher, year, edition, pages
2018. Vol. 536, no 1, p. 261-271
Keywords [en]
Controlled release, Ethyl cellulose, Film coating, Hydroxypropyl cellulose, Manufacturing conditions, Molecular weight, Phase separation, Polymer blend, alcohol, hydroxypropylcellulose, polymer, water, Article, chemical structure, controlled drug release, controlled study, priority journal, water permeability
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-33245DOI: 10.1016/j.ijpharm.2017.10.012Scopus ID: 2-s2.0-85035785089OAI: oai:DiVA.org:ri-33245DiVA, id: diva2:1182399
Note

 Funding text: This work was part of the VINN Excellence Centre SuMo Biomaterials.

Available from: 2018-02-13 Created: 2018-02-13 Last updated: 2018-08-20Bibliographically approved

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