The Plantrose® technology is a promising biorefinery method which enables the production of C5 and C6 sugars from different lignocellulosics using sub- and supercritical water in a two-step process. The lignin rich solids after carbohydrate hydrolysis containing various amounts of residual cellulose are trademarked as OmnoTM polymers. The reactivity and bonding performance of different Omno polymers in direct partial substitution of phenol-formaldehyde adhesive resins (PF) for the manufacture of oriented strand board (OSB) and softwood plywood were evaluated by a fast bench screening test using the Automatic Bond Evaluation System (ABES) and by pilot trials on the production and testing of wood panels. The results showed that about 1/3 of commercial glues could be successfully substituted by Omno polymers without any significant drop in the adhesive reactivity and properties of the resulting wood panels. Selected Omno polymers had superior performance as compared to high-purity pulping lignins (Kraft, soda and organosolv) due to a positive effect of the residual cellulose in the Omnopolymers on the adhesive performance. Hardwood lignins had no disadvantages as compared to various softwood lignins, in strict contrast to the current dogma.