The use of dispersion-managed (DM) solitons for 160-Gb/s data transmission in fiber lines where the period of dispersion management is much shorter than the amplifier spacing is investigated through numerical simulations. It is shown that DM solitons outperform both standard solitons and “quasi-linear” return-to-zero (RZ) pulses. The dispersion tolerance is limited by pulse-to-pulse interactions and Gordon–Haus jitter and decreases with increasing transmission distance.