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Lubrication synergy: Mixture of hyaluronan and dipalmitoylphosphatidylcholine (DPPC) vesicles
KTH Royal Institute of Technology, Sweden.
KTH Royal Institute of Technology, Sweden.
Institute for Materials Research, Germany.
Institute for Materials Research, Germany.
Show others and affiliations
2017 (English)In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 488, p. 225-233Article in journal (Refereed) Published
Abstract [en]

Phospholipids and hyaluronan have been implied to fulfil important roles in synovial joint lubrication. Since both components are present in synovial fluid, self-assembly structures formed by them should also be present. We demonstrate by small angle X-ray scattering that hyaluronan associates with the outer shell of dipalmitoylphophatidylcholine (DPPC) vesicles in bulk solution. Further, we follow adsorption to silica from mixed hyaluronan/DPPC vesicle solution by Quartz Crystal Microbalance with Dissipation measurements. Atomic Force Microscope imaging visualises the adsorbed layer structure consisting of non-homogeneous phospholipid bilayer with hyaluronan/DPPC aggregates on top. The presence of these aggregates generates a long-range repulsive surface force as two such surfaces are brought together. However, the aggregates are easily deformed, partly rearranged into multilayer structures and partly removed from between the surfaces under high loads. These layers offer very low friction coefficient (<0.01), high load bearing capacity (≈23 MPa), and self-healing ability. Surface bound DPPC/hyaluronan aggregates provide a means for accumulation of lubricating DPPC molecules on sliding surfaces.

Place, publisher, year, edition, pages
2017. Vol. 488, p. 225-233
Keywords [en]
Adsorption, AFM imaging, Dipalmitoylphosphatidylcholine (DPPC), Friction, Hyaluronan, Lubrication, QCM-D, Self-assembly, Small-angle X-ray scattering, Surface forces, Aggregates, Atomic force microscopy, Crystal atomic structure, Crystallography, Hyaluronic acid, Multilayers, Phospholipids, Quartz crystal microbalances, Self assembly, X ray scattering, Adsorbed layer structure, Dipalmitoyl phosphatidylcholine, Low friction coefficients, Quartz crystal microbalance with dissipation, Repulsive surface forces, dipalmitoylphosphatidylcholine, lipid bilayer, silicon dioxide, solution and solubility, biomechanics, chemical model, chemistry, quartz crystal microbalance, 1, 2-Dipalmitoylphosphatidylcholine, Biomechanical Phenomena, Lipid Bilayers, Models, Chemical, Quartz Crystal Microbalance Techniques, Solutions
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Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-31035DOI: 10.1016/j.jcis.2016.10.091Scopus ID: 2-s2.0-84994491737OAI: oai:DiVA.org:ri-31035DiVA, id: diva2:1138225
Note

Funding details: CSC, China Scholarship Council; Funding text: MW acknowledges a stipend from China Scholarship Council (CSC). AR acknowledges funding from the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7/2007-2013/ under REA grant agreement n 290251. We gratefully acknowledge technical support from Clement Blanchet (EMBL) at the P12 BioSAXS beamline (EMBL/DESY, PETRA III). We wish to acknowledge the financial support by the BMBF-project 05K2012 within the Joint International Research Project Röntgen-Angström-Cluster.

Available from: 2017-09-04 Created: 2017-09-04 Last updated: 2017-09-04Bibliographically approved

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