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Deposition efficiency of inhaled particles (15-5000 nm) related to breathing pattern and lung function: An experimental study in healthy children and adults
RISE - Research Institutes of Sweden, Bioscience and Materials, Chemistry, Materials and Surfaces. Lund University, Sweden.ORCID iD: 0000-0001-8650-4741
Lund University, Sweden.
SUS, Sweden.
Lund University, Sweden.
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2017 (English)In: Particle and Fibre Toxicology, ISSN 1743-8977, E-ISSN 1743-8977, Vol. 14, no 1, article id 10Article in journal (Refereed) Published
Abstract [en]

Background: Exposure to airborne particles has a major impact on global health. The probability of these particles to deposit in the respiratory tract during breathing is essential for their toxic effects. Observations have shown that there is a substantial variability in deposition between subjects, not only due to respiratory diseases, but also among individuals with healthy lungs. The factors determining this variability are, however, not fully understood. Method: In this study we experimentally investigate factors that determine individual differences in the respiratory tract depositions of inhaled particles for healthy subjects at relaxed breathing. The study covers particles of diameters 15-5000 nm and includes 67 subjects aged 7-70 years. A comprehensive examination of lung function was performed for all subjects. Principal component analyses and multiple regression analyses were used to explore the relationships between subject characteristics and particle deposition. Results: A large individual variability in respiratory tract deposition efficiency was found. Individuals with high deposition of a certain particle size generally had high deposition for all particles <3500 nm. The individual variability was explained by two factors: breathing pattern, and lung structural and functional properties. The most important predictors were found to be breathing frequency and anatomical airway dead space. We also present a linear regression model describing the deposition based on four variables: tidal volume, breathing frequency, anatomical dead space and resistance of the respiratory system (the latter measured with impulse oscillometry). Conclusions: To understand why some individuals are more susceptible to airborne particles we must understand, and take into account, the individual variability in the probability of particles to deposit in the respiratory tract by considering not only breathing patterns but also adequate measures of relevant structural and functional properties.

Place, publisher, year, edition, pages
2017. Vol. 14, no 1, article id 10
Keywords [en]
Aerosols, Airborne particles, Airway dead space, Individual variability, Inhalation, Lung dose, NanoSafety, Particle lung deposition, Respiratory tract deposition
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-30966DOI: 10.1186/s12989-017-0190-8Scopus ID: 2-s2.0-85018416270OAI: oai:DiVA.org:ri-30966DiVA, id: diva2:1138222
Note

 Funding details: 2009-01117, VINNOVA; Funding details: 621-2011-3560, VR, Vetenskapsrådet; Funding text: This research was supported by the Swedish Governmental Agency for Innovation Systems, VINNOVA (Project 2009-01117), the Swedish Research Council for Environmental, Agricultural Sciences and Spatial Planning, FORMAS (Projects 2009-1294, 2014-7613) and the Swedish Research Council (Project 621-2011-3560). This research was supported by the Swedish Governmental Agency for Innovation Systems, VINNOVA (Project 2009-01117), the Swedish Research Council for Environmental, Agricultural Sciences and Spatial Planning, FORMAS (Projects 2009-1294, 2014-7613) and the Swedish Research Council (Project 621-2011-3560). The funding bodies had no influence on the design of the study and collection, analysis, and interpretation of the data, or in writing the manuscript.

Available from: 2017-09-04 Created: 2017-09-04 Last updated: 2018-03-08Bibliographically approved

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