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Porous calcium carbonate as a carrier material to increase the dissolution rate of poorly soluble flavouring compounds
RISE - Research Institutes of Sweden, Bioscience and Materials, Chemistry and Materials.ORCID iD: 0000-0001-9162-9143
RISE - Research Institutes of Sweden, Bioscience and Materials, Surface, Process and Formulation.
Omya International AG, Switzerland ; Aalto University, Finland.
Omya International AG, Switzerland.
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2017 (English)In: Food & Function, ISSN 2042-6496, E-ISSN 2042-650X, Vol. 8, no 4, p. 1627-1640Article in journal (Refereed) Published
Abstract [en]

Two different food grade functionalised porous calcium carbonates (FCC), with different pore size and pore size distributions, were characterised and used as carrier materials to increase the dissolution rate of poorly soluble flavouring compounds in aqueous solution. The loading level was varied between 1.3% by weight (wt%) and 35 wt%, where the upper limit of 35 wt% was the total maximum loading capacity of flavouring compound in FCC based on the fraction of the total weight of FCC plus flavouring compound. Flavouring compounds (l-carvone, vanillin, and curcumin) were selected based on their difference in hydrophilicity and capacity to crystallise. Release kinetic studies revealed that all flavouring compounds showed an accelerated release when loaded in FCC compared to dissolution of the flavouring compound itself in aqueous medium. The amorphous state and/or surface enlargement of the flavouring compound inside or on FCC explains the faster release. The flavouring compounds capable of crystallising (vanillin and curcumin) were almost exclusively amorphous within the porous FCC material as determined by X-ray powder diffraction one week after loading and after storing the loaded FCC material for up to 9 months at room temperature. A small amount of crystalline vanillin and curcumin was detected in the FCC material with large pores and high flavouring compound loading (≥30 wt%). Additionally, two different loading strategies were evaluated, loading by dissolving the flavouring compound in acetone or loading by a hot melt method. Porosimetry data showed that the melt method was more efficient in filling the smallest pores (<100 nm). The main factor influencing the release rate appears to be the amorphous state of the flavouring compound and the increase in exposed surface area. The confinement in small pores prevents crystallisation of the flavouring compounds during storage, providing a stable amorphous form retaining high release rate also after storage.

Place, publisher, year, edition, pages
2017. Vol. 8, no 4, p. 1627-1640
Keywords [en]
Acetone, Calcium, Calcium carbonate, Digital storage, Dissolution, Food storage, Pore size, Solutions, X ray powder diffraction, Carrier material, Compound loadings, Different pore sizes, Dissolution rates, Exposed surfaces, Maximum loading, Porous calcium carbonates, Release kinetics, Loading, flavoring agent, chemistry, crystallization, kinetics, porosity, solubility, X ray diffraction, Flavoring Agents, X-Ray Diffraction
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Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-30987DOI: 10.1039/c6fo01579dScopus ID: 2-s2.0-85018795620OAI: oai:DiVA.org:ri-30987DiVA, id: diva2:1138026
Available from: 2017-09-04 Created: 2017-09-04 Last updated: 2018-08-15Bibliographically approved

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Lundin Johnson, Maria

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