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High performance micro-flow cytometer based on optical fibres
RISE - Research Institutes of Sweden, ICT, Acreo. KTH Royal Institute of Technology, Sweden.
KTH Royal Institute of Technology, Sweden.
KTH Royal Institute of Technology, Sweden.
KTH Royal Institute of Technology, Sweden.
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2017 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, no 1, article id 5628Article in journal (Refereed) Published
Abstract [en]

Flow cytometry is currently the gold standard for analysis of cells in the medical laboratory and biomedical research. Fuelled by the need of point-of-care diagnosis, a significant effort has been made to miniaturize and reduce cost of flow cytometers. However, despite recent advances, current microsystems remain less versatile and much slower than their large-scale counterparts. In this work, an all-silica fibre microflow cytometer is presented that measures fluorescence and scattering from particles and cells. It integrates cell transport in circular capillaries and light delivery by optical fibres. Single-stream cell focusing is performed by Elasto-inertial microfluidics to guarantee accurate and sensitive detection. The capability of this technique is extended to high flow rates (up to 800 μl/min), enabling a throughput of 2500 particles/s. The robust, portable and low-cost system described here could be the basis for a point-of-care flow cytometer with a performance comparable to commercial systems. © 2017 The Author(s).

Place, publisher, year, edition, pages
2017. Vol. 7, no 1, article id 5628
National Category
Computer and Information Sciences
Identifiers
URN: urn:nbn:se:ri:diva-30778DOI: 10.1038/s41598-017-05843-7Scopus ID: 2-s2.0-85025168074OAI: oai:DiVA.org:ri-30778DiVA, id: diva2:1135475
Available from: 2017-08-23 Created: 2017-08-23 Last updated: 2018-10-12Bibliographically approved

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