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Assessment of Novel Long-Lasting Ceria-Stabilized Zirconia-Based Ceramics with Different Surface Topographies as Implant Materials
University of Freiburg, Germany.
University of Freiburg, Germany.
University of Freiburg, Germany.
University of Freiburg, Germany.
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2017 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 27, no 40, article id 1702512Article in journal (Refereed) Published
Abstract [en]

The development of long-lasting zirconia-based ceramics for implants, which are not prone to hydrothermal aging, is not satisfactorily solved. Therefore, this study is conceived as an overall evaluation screening of novel ceria-stabilized zirconia-alumina-aluminate composite ceramics (ZA8Sr8-Ce11) with different surface topographies for use in clinical applications. Ceria-stabilized zirconia is chosen as the matrix for the composite material, due to its lower susceptibility to aging than yttria-stabilized zirconia (3Y-TZP). This assessment is carried out on three preclinical investigation levels, indicating an overall biocompatibility of ceria-stabilized zirconia-based ceramics, both in vitro and in vivo. Long-term attachment and mineralized extracellular matrix (ECM) deposition of primary osteoblasts are the most distinct on porous ZA8Sr8-Ce11p surfaces, while ECM attachment on 3Y-TZP and ZA8Sr8-Ce11 with compact surface texture is poor. In this regard, the animal study confirms the porous ZA8Sr8-Ce11p to be the most favorable material, showing the highest bone-to-implant contact values and implant stability post implantation in comparison with control groups. Moreover, the microbiological evaluation reveals no favoritism of biofilm formation on the porous ZA8Sr8-Ce11p when compared to a smooth control surface. Hence, together with the in vitro in vivo assessment analogy, the promising clinical potential of this novel ZA8Sr8-Ce11 as an implant material is demonstrated. 

Place, publisher, year, edition, pages
Wiley-VCH Verlag , 2017. Vol. 27, no 40, article id 1702512
Keywords [en]
Alumina, Biocompatibility, Ceramic materials, Surface topography, Zirconia, Bacterial adhesion, Human osteoblast, Implant materials, Osseointegration, Zirconia based composites, Yttria stabilized zirconia
National Category
Medical Materials
Identifiers
URN: urn:nbn:se:ri:diva-30368DOI: 10.1002/adfm.201702512Scopus ID: 2-s2.0-85026730768OAI: oai:DiVA.org:ri-30368DiVA, id: diva2:1135329
Available from: 2017-08-23 Created: 2017-08-23 Last updated: 2018-02-28Bibliographically approved

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