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Ferroelectric surfaces for cell release
Linköping University, Sweden.
Linköping University, Sweden.
RISE - Research Institutes of Sweden, ICT, Acreo.
RISE - Research Institutes of Sweden, ICT, Acreo.
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2017 (English)In: Synthetic metals, ISSN 0379-6779, E-ISSN 1879-3290, Vol. 228, 99-104 p.Article in journal (Refereed) Published
Abstract [en]

Adherent cells cultured in vitro must usually, at some point, be detached from the culture substrate. Presently, the most common method of achieving detachment is through enzymatic treatment which breaks the adhesion points of the cells to the surface. This comes with the drawback of deteriorating the function and viability of the cells. Other methods that have previously been proposed include detachment of the cell substrate itself, which risks contaminating the cell sample, and changing the surface energy of the substrate through thermal changes, which yields low spatial resolution and risks damaging the cells if they are sensitive to temperature changes. Here cell culture substrates, based on thin films of the ferroelectric polyvinylidene fluoride trifluoroethylene (PVDF-TrFE) co-polymer, are developed for electroactive control of cell adhesion and enzyme-free detachment of cells. Fibroblasts cultured on the substrates are detached through changing the direction of polarization of the ferroelectric substrate. The method does not affect subsequent adhesion and viability of reseeded cells.

Place, publisher, year, edition, pages
Elsevier Ltd , 2017. Vol. 228, 99-104 p.
Keyword [en]
Cell adhesion; Cell culture; Cells; Ferroelectric films; Ferroelectricity; Polymer films; Substrates; Tissue regeneration, Bioelectronics; Cell culture substrate; Cell release; Enzymatic treatments; Ferroelectric substrate; Ferroelectric surfaces; Polyvinylidene fluorides; Temperature changes, Cytology
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Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-30043DOI: 10.1016/j.synthmet.2017.04.013Scopus ID: 2-s2.0-85018478202OAI: oai:DiVA.org:ri-30043DiVA: diva2:1119577
Available from: 2017-07-04 Created: 2017-07-04 Last updated: 2017-11-20Bibliographically approved

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