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Layer-by-layer assembled magnetic prednisolone microcapsules (MPC) for controlled and targeted drug release at rheumatoid arthritic joints
Anna University, Tiruchirappalli, Tamil Nadu, India.
Anna University, Tiruchirappalli, Tamil Nadu, India.
Anna University, Tiruchirappalli, Tamil Nadu, India.
RISE - Research Institutes of Sweden, ICT, Acreo.
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2017 (English)In: Journal of Magnetism and Magnetic Materials, ISSN 0304-8853, E-ISSN 1873-4766, Vol. 427, 258-267 p.Article in journal (Refereed) Published
Abstract [en]

We report here in about the formulation and evaluation of Magnetic Prednisolone Microcapsules (MPC) developed in order to improve the therapeutic efficacy relatively at a low dose than the conventional dosage formulations by means of magnetic drug targeting and thus enhancing bioavailability at the arthritic joints. Prednisolone was loaded to poly (sodium 4-styrenesulfonate) (PSS) doped calcium carbonate microspheres confirmed by the decrease in surface area from 97.48 m2/g to 12.05 of m2/g by BET analysis. Adsorption with oppositely charged polyelectrolytes incorporated with iron oxide nanoparticles was confirmed through zeta analysis. Removal of calcium carbonate core yielded MPC with particle size of ~3.48 µm, zeta potential of +29.7 mV was evaluated for its magnetic properties. Functional integrity of MPC was confirmed through FT-IR spectrum. Stability studies were performed at 25 °C±65% relative humidity for 60 days showed no considerable changes. Further the encapsulation efficiency of 63%, loading capacity of 18.2% and drug release of 88.3% for 36 h and its kinetics were also reported. The observed results justify the suitability of MPC for possible applications in the magnetic drug targeting for efficient therapy of rheumatoid arthritis.

Place, publisher, year, edition, pages
2017. Vol. 427, 258-267 p.
Keyword [en]
Layer-by-layer, Magnetic microcapsules, Prednisolone, Rheumatoid arthritis, Biochemistry, Calcium, Calcium carbonate, Diseases, Drug dosage, Encapsulation, Microstructure, Particle size, Polyelectrolytes, Encapsulation efficiency, Layer by layer, Magnetic drug targeting, Oppositely charged polyelectrolytes, Polysodium 4-styrenesulfonate, Magnetism
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-29331DOI: 10.1016/j.jmmm.2016.11.030Scopus ID: 2-s2.0-85008263813OAI: oai:DiVA.org:ri-29331DiVA: diva2:1094975
Available from: 2017-05-11 Created: 2017-05-11 Last updated: 2017-05-11Bibliographically approved

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