Stricter emission requirements have led to ship operation on low flashpoint fuels, such as liquefied natural gas and methanol. These differ in many ways from traditional fuels (e.g. heavy fuel oil and marine gas oil), but requirements and guidelines for fire detection and extinguishment have been sparse. This was addressed in the proFLASH project, first theoretically and then experimentally. This report documents the experimental part of the project, focusing on methanol, and gives technical guidance for fire detection and extinguishing systems. It was for example concluded that methanol flames exhibit similar radiation to ethanol in the IR spectrum, despite limited observability in the visual spectrum. Approved IR flame detectors (tested against ethanol) are thereby likely suitable to detect methanol fire; tested detectors could even detect fully obstructed methanol fire. The design concentration of carbon dioxide gas fire-extinguishing systems should be increased from 40 % to 55 % to achieve the same safety margin for methanol as for traditional fuels. The primary extinguishing mechanism of a water-based fire-extinguishing system used against methanol is dilution, but almost 90 % water may be necessary for extinguishment. Furthermore, dilution makes the methanol flames increasingly invisible. It is recommended to use alcohol resistant foam injection with fixed water-based extinguishing systems, since this significantly reduces the time required for extinguishment. The effectiveness of the system depends on the foam/water application rate. Hence, a higher discharge rate is more effective and a concealed pool is difficult to extinguish. In different compartment fire test scenarios, water-spray with foam injection was more effective against methanol than water-spray without foam against standardized fuels. High and low pressure water mist performed better than water spray against standardized fuels but worse against methanol (with foam injection).