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The interaction of wood nanocellulose dressings and the wound pathogen P. aeruginosa
Cardiff University School of Dentistry, UK.
NTNU, Norway.
Cardiff University School of Dentistry, UK.
Cardiff University School of Dentistry, UK.
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2017 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 157, 1955-1962 p.Article in journal (Refereed) Published
Abstract [en]

Chronic wounds pose an increasingly significant worldwide economic burden (over £1 billion per annum in the UK alone). With the escalation in global obesity and diabetes, chronic wounds will increasingly be a significant cause of morbidity and mortality. Cellulose nanofibrils (CNF) are highly versatile and can be tailored with specific physical properties to produce an assortment of three-dimensional structures (hydrogels, aerogels or films), for subsequent utilization as wound dressing materials. Growth curves using CNF (diameter <20 nm) in suspension demonstrated an interesting dose-dependent inhibition of bacterial growth. In addition, analysis of biofilm formation (Pseudomonas aeruginosa PAO1) on nanocellulose aerogels (20 g/m2) revealed significantly less biofilm biomass with decreasing aerogel porosity and surface roughness. Importantly, virulence factor production by P. aeruginosa in the presence of nanocellulose materials, quantified for the first time, was unaffected (p > 0.05) over 24 h. These data demonstrate the potential of nanocellulose materials in the development of novel dressings that may afford significant clinical potential.

Place, publisher, year, edition, pages
2017. Vol. 157, 1955-1962 p.
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Biomaterials Science Nano Technology
Identifiers
URN: urn:nbn:se:ri:diva-27887DOI: 10.1016/j.carbpol.2016.11.080Scopus ID: 2-s2.0-85006120446OAI: oai:DiVA.org:ri-27887DiVA: diva2:1066211
Available from: 2017-01-17 Created: 2017-01-17 Last updated: 2017-10-06Bibliographically approved

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