Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The influence of the molecular weight of the water-soluble polymer on phase-separated films for controlled release
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Food and Bioscience. Chalmers University of Technology, Gothenburg, Sweden.
Chalmers University of Technology, Gothenburg, Sweden.
Chalmers University of Technology, Gothenburg, Sweden.
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Food and Bioscience. Chalmers University of Technology, Gothenburg, Sweden.
Show others and affiliations
2016 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 511, no 1, 223-235 p.Article in journal (Refereed) Published
Abstract [en]

Hydroxypropyl cellulose (HPC) and ethyl cellulose (EC) can be used for extended release coatings, where the water-soluble HPC may act as a pore former. The aim was to investigate the effect of the molecular weight of HPC on the microstructure and mass transport in phase-separated freestanding EC/HPC films with 30% w/w HPC. Four different HPC grades were used, with weight averaged molecular weights (Mw) of 30.0 (SSL), 55.0 (SL), 83.5 (L) and 365 (M) kg/mol. Results showed that the phase-separated structure changed from HPC-discontinuous to bicontinuous with increasing Mw of HPC. The film with the lowest Mw HPC (SSL) had unconnected oval-shaped HPC-rich domains, leaked almost no HPC and had the lowest water permeability. The remaining higher Mw films had connected complex-shaped pores, which resulted in higher permeabilities. The highest Mw film (M) had the smallest pores and very slow HPC leakage, which led to a slow increase in permeability. Films with grade L and SL released most of their HPC, yet the permeability of the L film was three times higher due to greater pore connectivity. It was concluded that the phase-separated microstructure, the level of pore percolation and the leakage rate of HPC will be affected by the choice of HPC Mw grade used in the film and this will in turn have strong impact on the film permeability. © 2016

Place, publisher, year, edition, pages
2016. Vol. 511, no 1, 223-235 p.
Keyword [en]
Controlled release, Ethyl cellulose, Film coating, Hydroxypropyl cellulose, Molecular weight, Pellet formulation, Phase separation
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-27607DOI: 10.1016/j.ijpharm.2016.06.058Scopus ID: 2-s2.0-84978264816OAI: oai:DiVA.org:ri-27607DiVA: diva2:1059683
Available from: 2016-12-22 Created: 2016-12-21 Last updated: 2017-02-10Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus
By organisation
SP Food and BioscienceStructure Design
In the same journal
International Journal of Pharmaceutics
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 56 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
v. 2.26.0