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Small calibre biosynthetic bacterial cellulose blood vessels: 13-months patency in a sheep model
YKI – Ytkemiska institutet.
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2012 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 46, no 1, 57-62 p.Article in journal (Refereed)
Abstract [en]

OBJECTIVES: Many patients in need of bypass surgery lack graft material and current synthetic alternatives have poor performance. A 4 mm vascular graft composed of bacterial cellulose (BC) was developed and tested in pilot study in a large animal model. DESIGN: BC is a biopolymer made by the bacteria acetobacter xylinum. BC grafts (n = 16) with 4 cm length and 4 mm internal diameter were implanted bilaterally in the carotid arteries of eight sheep. No long-term antithrombotic therapy was administered. Patency was assessed with ultrasound. Histology, immunohistochemistry, and electron microscopy were performed after explantation. RESULTS: Fifty percent of the grafts occluded within two weeks. One animal died with patent grafts after 14 days. In the three remaining animals 5/6 grafts were patent after nine months. Two animals were followed 13 months after implantation with 3/4 grafts patent at explantation. All patent grafts had confluent endothelial-like cells. CONCLUSIONS: Biosynthetic small calibre vascular grafts made from BC can be patent for up to 13 months in sheep carotid arteries. BC is a potential material for small calibre grafts but patency in animal models needs to be improved before clinical studies can be planned.

Place, publisher, year, edition, pages
2012. Vol. 46, no 1, 57-62 p.
Keyword [en]
Small calibre biosynthetic bacterial cellulose blood vessles: 13-months patency in a sheep model
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-27465OAI: oai:DiVA.org:ri-27465DiVA: diva2:1054470
Note
A3136Available from: 2016-12-08 Created: 2016-12-08Bibliographically approved

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