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Preparation and evaluation of sterically stabilized liposomes: colloidal stability, serum stability, macrophage uptake and toxicology
YKI – Ytkemiska institutet.
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1990 (English)In: Journal of Pharmaceutical Sciences, ISSN 0022-3549, E-ISSN 1520-6017, Vol. 79, 667-671 p.Article in journal (Refereed)
Abstract [en]

Sterically stabilized liposomes were produced by incorporating a nonionic surfactant, polysorbate 80 (Tween 80), into the lipid bilayer. The sterically stabilized liposomes exhibited a superior entrapment stability compared with surfactant-free liposomes (i.e., liposomes prepared with lipids and cholesterol). The sterically stabilized liposomes were stable at high calcium ion concentrations, and liposome-entrapped carboxyflourescein was retained within the stabilized liposomes in the presence of serum for at least 5 h. The macrophage uptake of the sterically stabilized liposomes was comparable to that of liposomes containing lipids and cholesterol. The sterically stabilized liposomes were non-toxic, in concentrations up to 3.0 mM, to macrophages. These results indicate that polysorbate 80 can be used to produce stable liposomes without changing the uniqe macrophage distribution of this drug delivery system.

Place, publisher, year, edition, pages
1990. Vol. 79, 667-671 p.
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-26902OAI: oai:DiVA.org:ri-26902DiVA: diva2:1053905
Note
A601Available from: 2016-12-08 Created: 2016-12-08Bibliographically approved

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