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Particle size and density in spray drying - effects of carbohydrate properties
YKI – Ytkemiska institutet.
2005 (English)In: Journal of Pharmaceutical Sciences, ISSN 0022-3549, E-ISSN 1520-6017, Vol. 94, 2049-2060 p.Article in journal (Refereed)
Abstract [en]

The purpose of this study was to examine some fundamental aspects of the particle formation during spray drying, related to particle size and density. Particles were prepared in a laboratory spray dryer from carbohydrates with different solubility and crystallization propensity, such as lactose, mannitol and sucrose/dextran 4:1. The feed concentrations ranged from 1% w/w to saturated and the size of droplets and particles were measured by laser diffraction. Particles were also characterized by various microscopy techniques (i.e. scanning electron microscopy, confocal laser scanning microscopy and light microscopy), differential scanning calorimetry, gas adsorption, and gas pycnometry. As demonstrated larger particles could be obtained by either increasing the droplet size during atomization; increasing the concentration of the feed solution; or decreasing the solubility of the solute. The apparent particle density was found negatively correlated to the feed concentration. Due to the non-linear relationship between the feed concentration and the particle size, it was concluded that higher solids load may cause an increase in the effective particle density and that the reduction in the apparent particle density was a result of a gradually less permeable particle surface. Further, the crystallization propensity of the carbohydrate influenced the particle formation and resulted in either hollow or porous particles

Place, publisher, year, edition, pages
2005. Vol. 94, 2049-2060 p.
Keyword [en]
Spray drying, particle formation, droplet size, particle size, apparent particle density, effective particle density, pycnometry, BET, SEM, CLSM
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-26898OAI: oai:DiVA.org:ri-26898DiVA: diva2:1053901
Note
A1724Available from: 2016-12-08 Created: 2016-12-08Bibliographically approved

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