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An atomic force microscopy approach for assessment of particle density applied to single spray-dried carbohydrate particles
YKI – Ytkemiska institutet.
2007 (English)In: Journal of Pharmaceutical Sciences, ISSN 0022-3549, E-ISSN 1520-6017, Vol. 96, no 4, p. 905-912Article in journal (Refereed)
Abstract [en]

To evaluate an atomic force microscopy (AFM) approach for effective density analysis of single spray dried carbohydrate particles in order to investigate the internal structure of the particles. In addition, the AFM method was compared to an established technique, that is gas pycnometry. Resonant frequency AFM analysis was employed for determination of the mass of individual particles of spray-dried lactose, mannitol, and a mixture of sucrose/dextran (4:1). The effective particle density was calculated using the diameter of the spherical particles obtained from light microscopy. The apparent particle density was further analyzed with gas pycnometry. It was observed by microscopy that particles appeared either ‘‘solid’’ or ‘‘hollow.’’ A solid appearance applied to an effective particle density close to the true density of the material, whereas a density around 1 g/cm3 corresponded to a hollow appearance. However, carbohydrates, which crystallized during spray drying, for example, mannitol appeared solid but the average effective particle density was 0.95 g/cm3, indicating a continuous but porous structure. AFM measurements of effective particle density corroborate the suggestion of differences in particle structure caused by the varying propensity of carbohydrates to crystallize during spray drying, resulting in mainly either amorphous hollow orcrystalline porous particles.

Place, publisher, year, edition, pages
2007. Vol. 96, no 4, p. 905-912
Keywords [en]
particle density, atomic force microscopy (AFM), gas pycnometry, microparticles, spray drying, morphology, crystallization, amorphous
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-26897OAI: oai:DiVA.org:ri-26897DiVA, id: diva2:1053900
Note
A1731Available from: 2016-12-08 Created: 2016-12-08 Last updated: 2017-11-29Bibliographically approved

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