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Ellipsometry studies of protein adsorption at lipid surfaces
YKI – Ytkemiska institutet.
1994 (English)In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 168, 247-254 p.Article in journal (Refereed)
Abstract [en]

The adsorption of human serum albumin (HSA), IgG and fibrinogen at lipid surfaces was investigated with in situ ellipsometry. It was found that the adsorbed amount of these proteins at phosphatidylcholine (PC) and phosphatidylinositol (PI) surfaces was smaller than that at (hydrophilic) silica and (hydrophobic) methylated silica surfaces. PC and PI surfaces were quite similar with respect to the adsorption of these proteins. More precisely, the adsorption of HSA, IgG and fibrinogen at PC is lower than that at methylated silica roughly by a factor of 3, 15 and 100, respectively, corresponding to an adsorbed amount of 0.30 mg/m2, 0.20 mg/m2 and 0.05 mg/m2, respectively. The adsorption of lysozyme at PI was significantly larger than that of HSA, IgG and fibrinogen, but still smaller than that of lysozyme at silica and methylated silica. At phosphatidic acid (PA), the adsorption of all the proteins investigated was significantly larger than that at PC and PI. In fact, the adsorption at PA resembles that at silica and methylated silica more than that at PC and PI. These findings are correlated to previous results on the influence of the surface composition of colloidal drug carriers on their endocytosis.

Place, publisher, year, edition, pages
1994. Vol. 168, 247-254 p.
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-26766OAI: oai:DiVA.org:ri-26766DiVA: diva2:1053769
Note
A922Available from: 2016-12-08 Created: 2016-12-08Bibliographically approved

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