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Effect of chain density on inhibition of protein adsorption by poly(ethylene glycol) based coatings
YKI – Ytkemiska institutet.
1998 (English)In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 202, 507-517 p.Article in journal (Refereed)
Abstract [en]

The effect of interfacial chain density of poly( ethylene glycol) (PEG) on the adsorption of serum proteins was investigated by in situ ellipsometry. For terminal covalently grafted PEG of molecular weight 5000 an increased grafting density results in serum protein adsorption. At high interfacial chain density ( É 0.1 chain/nm2) , efficient protein rejection was observed, irrespective of the coupling chemistry used. Strongly adsorbed PEG-containing polymers behaved similarly to covalently attached PEG regarding inhibition of protein adsorption, independent of the nature of the underlying surface. The results are discussed in relation to the importance of the protein size in protein rejection by PEG coatings.

Place, publisher, year, edition, pages
1998. Vol. 202, 507-517 p.
Keyword [en]
Adsorption, ellipsometry: PEG, poly(ethylene glycol), polymer, protein
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-26724OAI: oai:DiVA.org:ri-26724DiVA: diva2:1053727
Note
A1032Available from: 2016-12-08 Created: 2016-12-08Bibliographically approved

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