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Ellipsometry studies of lipoprotein adsorption
YKI – Ytkemiska institutet.
2000 (English)In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 224, 338-346 p.Article in journal (Refereed)
Abstract [en]

The adsorption of a number of lipoproteins, i.e., low-density lipoprotein (LDL), oxidized LDL (oxLDL), high-density lipoprotein (HDL), and lipoprotein (a), at silica and methylated silica as well as at the latter surface modified through adsorption of proteoheparan sulfate, was investigated with in situ ellipsometry at close to physiological conditions. It was found that LDL, oxLDL, HDL, and lipoprotein (a) all adsorbed more extensively at silica than at methylated silica. Upon exposure of the methylated silica surface to proteoheparan sulfate, this proteoglycan adsorbs through its hydrophobic moiety, thereby forming a layer similar to that in the biological system, with the polysaccharide chains forming brushes oriented toward the aqueous solution. Analogous to the biological system, both lipoprotein (a) and LDL were found to deposit at such surfaces, the latter particularly in the simultaneous presence of Ca2+. After HDL pre-exposure, however, no LDL deposition was observed, even at high LDL and Ca2+ concentrations. These findings correlate well with those obtained from clinical investigations on risk factors for atherosclerosis.

Place, publisher, year, edition, pages
2000. Vol. 224, 338-346 p.
Keyword [en]
Adsorption, arteriosclerosis, atherosclerosis, ellipsometry, HDL, LDL, lipoprotein (a), proteoglycans, proteoheparan sulfate
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-26710OAI: oai:DiVA.org:ri-26710DiVA: diva2:1053713
Note
A1331Available from: 2016-12-08 Created: 2016-12-08Bibliographically approved

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