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Ellipsometry and TIRF studies of adsorption processes in parenteral drug delivery
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
1997 (English)In: Interface science, ISSN 0927-7056, E-ISSN 1573-2746, Vol. 5, p. 159-167Article in journal (Refereed)
Abstract [en]

Ellipsometry and total internal reflection fluorescence spectroscopy (TIRF) were used for investigating adsorption processes of relevance for parenteral administration of colloidal drug carriers. Emphasis is put on discussing the effects of both protein and surface properties on the adsorption of serum proteins at phospholipid and other surfaces. Furthermore, the adsorption from multicomponent protein systems, such as blood, is addressed, and both competitive and associative adsorption phenomena discussed. The correlation between effects of the drug carrier surface properties on the serum protein adsorption and the circulation time and tissue distribution of colloidal drug carriers is also addressed. Finally, the potential of ellipsometry in another adsorption process of major importance for phagocytosis, i.e., the adsorption of colloidal particles to macroscopic or mesoscopic surfaces, is indicated by investigations of the adsorption of oil-in-water emulsion droplets at silica.

Place, publisher, year, edition, pages
1997. Vol. 5, p. 159-167
Keywords [en]
Adsorption, ellipsometry, opsonins, PEG, phospholipids, polymers, proteins, TIRF
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-26595OAI: oai:DiVA.org:ri-26595DiVA, id: diva2:1053598
Note
A1126Available from: 2016-12-08 Created: 2016-12-08 Last updated: 2020-12-01Bibliographically approved

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