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Preparation of submicron drug particles in lecithin-stabililized o/w emulsions I. Model studies of the precipitation of cholesteryl acetate
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, YKI – Ytkemiska institutet.
1992 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 84, p. 107-116Article in journal (Refereed)
Abstract [en]

Nanoparticles of a model drug, viz. cholesteryl acetate. were prepared. The cholesteryl acetate was dissolved in cyclohexane containing lecithin. The organic solution was emulsified in an aqueous solution containing a cosurfactant. A stable o/w-emulsion resulted. The solvent was evaporated from the emulsion and cholesteryl acetate precipitated in the emulsion droplets. The size of the particles was almost not affected by the cholesteryl acetate concentration in cyclohexane. Furthermore, the increase in particle size, as a result of an increased oil/water ratio was negligible. With a blend of phosphatidylcholine and sodium salt of glycocholic acid as emulsifiers, particle sizes down to 25 nm were obtained, The ratio between phosphatidylcholine and sodiumglycocholate seems to be critical. In increasing the ratio above 9/1, the suspension becomes more instable as is noticed by an increase in particle size during storage. The optimal conditions coincide with those giving an extensively swelling lamellar liquid crystalline phase containing phosphatidylcholine and sodiumglycocholate.

Place, publisher, year, edition, pages
1992. Vol. 84, p. 107-116
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-26592OAI: oai:DiVA.org:ri-26592DiVA, id: diva2:1053595
Note
A732Available from: 2016-12-08 Created: 2016-12-08 Last updated: 2020-12-01Bibliographically approved

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