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Vascular smooth muscle, a multiply feedback-coupled system of high versatility, modulation and cell-signaling variability
YKI – Ytkemiska institutet.
1997 (English)In: Int J Microcirc, ISSN 0167-6865 , Vol. 17, 360-373 p.Article in journal (Refereed)
Abstract [en]

Under normal conditions, the various vascular regulatory effector influences are interwoven in a dynamic, and not a static, circulatory system. The reaction of a smooth muscle cell is thus reflected only incompletely by the stationary activation curve `developed tension versus membrane potential'. The missing time domain in this relationship is a reflection of our as yet limited understanding of the system´s behavior in space and time. It should be emphasized that rythmogenic properties of vascular smooth muscle are closely coupled to a functioning circulation.The electrical and mechanical oscillations, which can be traced back to rhythmic activity of the active electrogenic Na+K+ pump, could originate in the allosteric qualities of the enzyme phosphofructokinase (PFK).Thus, PFK represents a rhythmogenic enzyme which may serve as an example of the connection between the biological properties on a molecular level and the spatiotemporal system`s behavior.The cardiovascular system and its rhythmicity may be dominated by only a few control points, one of which is distinguished by the viscoelastic properties of a blood flow sensor macromolecule.Therefore, the three prominent control points PFK, (Na++K+)-ATPase and flow sensor conformation -acting as negatively feedback-couple nonlinear synergetic order papameter are sufficient to initiate the periodic events in the cardiovascular system and to provide a plausible explanation for their causal origin.

Place, publisher, year, edition, pages
1997. Vol. 17, 360-373 p.
Keyword [en]
Vascular smooth muscle, spatiotemporal organization, slow waves, eigenoscillations, oscillatory domain, phosphofructokinase, (Na+K+)-ATPase, blood flow sensor, heparan sulfate proteoglycan, NADH fluorescence, tension, 24Na+ efflux, ellipsometry
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-26578OAI: oai:DiVA.org:ri-26578DiVA: diva2:1053581
Note
A1216Available from: 2016-12-08 Created: 2016-12-08Bibliographically approved

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