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Ellipsometry studies of the mucoadhesion of cellulose derivatives
YKI – Ytkemiska institutet.
1994 (English)In: Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, E-ISSN 1873-4367, Vol. 2, 463-470 p.Article in journal (Refereed)
Abstract [en]

The mucoadhesion of three different cellulose derivatives, ethyl(hydroxyethyl)cellulose (EHEC), hydrophobically modified hydroxyethyl cellulose (h-HEC) and a cationic cellulose derivative (amino cellulose), was investigated with in situ ellipsometry. In the measurements, gastric mucin from rat was first adsorbed onto hydrophobized silica, which provided good anchorage for the mucin layer and allowed a large amount of mucin to be adsorbed. Significant mucoadhesion was obtained for all three cellulose derivatives, indicating that either overall solvency effects, electrostatic interactions or hydrophobic groups may be used to obtain mucoadhesion in cellulose systems. Of the polymers used, EHEC showed the greatest tendency for adsorption, which may indicate that the first approach is preferable for obtaining efficient mucoadhesion. The addition of SDS was found to counteract mucoadhesion of EHEC.

Place, publisher, year, edition, pages
1994. Vol. 2, 463-470 p.
Keyword [en]
Cellulose, ellipsometry, ethyl(hydroxyethyl)cellulose, mucins, mucoadhesion, polymers
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-26501OAI: oai:DiVA.org:ri-26501DiVA: diva2:1053503
Note
A927Available from: 2016-12-08 Created: 2016-12-08Bibliographically approved

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