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Influence of ionic strength changes on the structure of pre-adsorbed salivary films. A response of a natural multi-component layer
YKI – Ytkemiska institutet.
2010 (English)In: Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, E-ISSN 1873-4367, Vol. 77, no 1, p. 31-39Article in journal (Refereed)
Abstract [en]

Salivary films coating oral surfaces are critically important for oral health. This study focuses on determining the underlying nature of this adsorbed film and how it responds to departures from physiological conditions due to changes in ionic strength. Under physiological conditions, it is found that pre-adsorbed in vitro salivary film on hydrophobic surfaces is present as a highly hydrated viscoelastic layer. We follow the evolution of this film in terms of its effective thickness, hydration and viscoelastic properties, as well as adsorbed mass of proteins, using complementary surface characterisation methods: a Surface Plasmon Resonance (SPR) and a Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D). Our results support a heterogeneous model for the structure of the salivary film with an inner dense anchoring layer and an outer highly extended hydrated layer. Further swelling of the film was observed upon decreasing the salt concentration down to 1 mM NaCl. However, upon exposure to deionised water, a collapse of the film occurs that was associated with the loss of water contained within the adsorbed layer. We suggest that the collapse in deionised water is driven by an onset of electrostatic attraction between different parts of the multi-component salivary film. It is anticipated that such changes could also occur when the oral cavity is exposed to food, beverage, oral care and pharmaceutical formulations where drastic changes to the structural integrity of the film is likely to have implications on oral health, sensory perception and product performance.

Place, publisher, year, edition, pages
2010. Vol. 77, no 1, p. 31-39
Keywords [en]
Influence of ionic strength changes on the structure of pre-adsorbed salivary films. A response of a natural multi-component layer Saliva, Adsorbed film, Surface Plasmon Resonance, Quartz Crystal Microbalance, Hydration, Viscoelastic properties
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-26388DOI: 10.1016/j.colsurfb.2009.12.022OAI: oai:DiVA.org:ri-26388DiVA, id: diva2:1053390
Note
A2095Available from: 2016-12-08 Created: 2016-12-08 Last updated: 2017-11-29Bibliographically approved

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CiteExportLink to record
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  • apa
  • harvard1
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  • de-DE
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  • en-US
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