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Confocal Raman microscopy for mapping phase segregation in individually dried particles composed of lactose and macromolecules
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
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2015 (English)In: Colloids and Surfaces A: Physicochemical and Engineering Aspects, ISSN 0927-7757, E-ISSN 1873-4359, Vol. 481, 229-236 p.Article in journal (Refereed)
Abstract [en]

The quality of powder is determined by its functionality such as dissolution, encapsulation and flowability. The functionality of powder is in turn determined by their primary properties such as morphology and composition which need to be studied. Hence morphology and surface composition has been largely investigated in spray dried powders and individually dried particles. On the contrary, there is only scarce information regarding the internal structure. With the aim of acquiring a better understanding of the localization of different ingredients in spray dried powders we have used confocal Raman microscopy to investigate the internal microstructure of individually dried particles. In this study three different macromolecules have been investigated: bovine serum albumin, hydroxypropyl methyl cellulose, and triblock co-polymer poloxamer in a lactose matrix are compared at various macromolecule to lactose ratios. The surface and internal component distribution in response to the macromolecule concentration has been established. For the first time phase segregation in particles during a short drying time range is shown. Macromolecules were enriched at the surface of the dried particles and a macromolecule depleted layer was observed below the surface. Macromolecule enriched domains were found segregated from the amorphous lactose matrix in the internal part of the particles. Confocal Raman microscopy was found to be a powerful tool for internal mapping in individually dried particles.

Place, publisher, year, edition, pages
2015. Vol. 481, 229-236 p.
Keyword [en]
Composition, Confocal raman microscopy, Individually dried particles, Mapping, Phase segregation, Confocal Raman microscopy for mapping phase segregation in individually dried particles composed of lactose and macromolecules
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-26379DOI: 10.1016/j.colsurfa.2015.04.044OAI: oai:DiVA.org:ri-26379DiVA: diva2:1053381
Note
A3500Available from: 2016-12-08 Created: 2016-12-08Bibliographically approved

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CiteExportLink to record
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