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Anionic biopolymers as blood flow sensors
YKI – Ytkemiska institutet.
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1996 (English)In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 11, 281-294 p.Article in journal (Refereed)
Abstract [en]

The finding of flow-dependent vasodilatation rests on the basic observation that with an increase in blood flow the vessels become wider, with a decrease the vascular smooth muscle cells contract. Proteoheparan sulphate could be the sensor macromolecule at the endothelial cell membrane-blood interface, that reacts on the shear stress generated by the flowing blood, and that informs and regulates the vascular smooth muscle cells via a signal transduction chain. This anionic biopolyelectrolyte possesses viscoelastic and specific ion binding properties which allow a change of its configuration in dependence on shear stress and electrostatic charge density. The blood flow sensor undergoes a conformational transition from a random coil to an extended filamentous state with increasing flow, whereby Na+ ions from the blood are bound. Owing to the intramolecular elastic recoil forces of proteoheparan sulphate the slowing of a flow rate causes an entropic coiling the expulsion of Na+ ions and thus an interruption of the signal chain. Under physiological conditions, the conformation and Na+ binding proved to be extremely Ca2+-sensitive while K+ and Mg2+ ions play a minor role for the susceptibility of the sensor. Via counterion migration of the bound Na+ ions along the sensor glycosaminoglycan side chains and following Na+ passage through an unspecific ion channel in the endothelial cell membrane, the signal transduction chain leads to a membrane depolarization with Ca2+ influx into the cells. This stimulates the EDRF/NO production and release from the endothelial cells. The consequence is vasodilatation.

Place, publisher, year, edition, pages
1996. Vol. 11, 281-294 p.
Keyword [en]
Anionic biopolymers, cation binding, ellipsometry, flow-dependent vasodilatation, proteoheparan sulphate, 23Na+ NMR, surface force studies
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-26332OAI: oai:DiVA.org:ri-26332DiVA: diva2:1053334
Note
A1046Available from: 2016-12-08 Created: 2016-12-08Bibliographically approved

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