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Validation and development of MTH1 inhibitors for treatment of cancer
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Process Development. (Substans och formulering)
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Process Development.
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Process Development.
Scilife Laboratory, Karolinska institutet, Solna.
2016 (English)In: Annals of Oncology, ISSN 0923-7534, E-ISSN 1569-8041Article in journal (Refereed) Published
Abstract [en]

Previously, we showed cancer cells rely on the MTH1 protein to prevent incorporation of otherwise deadly oxidised nucleotides into DNA and we developed MTH1 inhibitors which selectively kill cancer cells. Recently, several new and potent inhibitors of MTH1 were demonstrated to be non-toxic to cancer cells, challenging the utility of MTH1 inhibition as a target for cancer treatment.

Place, publisher, year, edition, pages
2016.
Keyword [en]
MTH1 cancer
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:ri:diva-26214DOI: 10.1093/annonc/mdw429OAI: oai:DiVA.org:ri-26214DiVA: diva2:1051320
Available from: 2016-12-01 Created: 2016-12-01 Last updated: 2016-12-01Bibliographically approved

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