Validation and development of MTH1 inhibitors for treatment of cancer

Warpman Berglund, U.; Sanjiv, K.; Gad, H.; Kalderén, C.; Koolmeister, T.; Pham, T.; Gokturk, C.; Jafari, R.; G., Maddalo; Seashore-Ludlow, B.; Chernobrovkin, A.; Manoilov, A.; Pateras, I. S.; Rasti, A.; Jemth, A.-S.; Almlöf, I.; Loseva, O.; Visnes, T.; Einarsdottir, B. O.; Gaugaz, F. Z.; Saleh, A.; Platzack, B.; Wallner, O. A.; Vallin, Karl; Henriksson, M.; Wakchaure, P.; Borhade, S.; Herr, P.; Kallberg, Y.; Baranczewski, P.; Homan, E. J.; Wiita, E.; Nagpal, V.; Meijer, T.; Schipper, Nicolaas; Rudd, S. D.; Bräutigam, L.; Lindqvist, A.; Filppula, A.; Lee, T-C.; Artursson, P.; Nilsson, J. A.; Gorgoulis, V. G.; Lehtiö, J.; Zubarev, R. A.; Scobie, M.; Helleday, T.

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Validation and development of MTH1 inhibitors for treatment of cancer

Warpman Berglund, U.

Science for Life Laboratory, Sweden.

Sanjiv, K.

Science for Life Laboratory, Sweden.

Gad, H.

Science for Life Laboratory, Sweden.

Kalderén, C.

Science for Life Laboratory, Sweden.

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2016 (English)In: Annals of Oncology, ISSN 0923-7534, E-ISSN 1569-8041, Vol. 27, no 12, p. 2275-2283Article in journal (Refereed) Published

Abstract [en]

Previously, we showed cancer cells rely on the MTH1 protein to prevent incorporation of otherwise deadly oxidised nucleotides into DNA and we developed MTH1 inhibitors which selectively kill cancer cells. Recently, several new and potent inhibitors of MTH1 were demonstrated to be non-toxic to cancer cells, challenging the utility of MTH1 inhibition as a target for cancer treatment.

Place, publisher, year, edition, pages

2016. Vol. 27, no 12, p. 2275-2283

Keywords [en]

MTH1, reactive oxygen species, cancer, small molecule inhibitors, DNA damage

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Cancer and Oncology

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URN: urn:nbn:se:ri:diva-26214DOI: 10.1093/annonc/mdw429Scopus ID: 2-s2.0-85031497285OAI: oai:DiVA.org:ri-26214DiVA, id: diva2:1051320

Available from: 2016-12-01 Created: 2016-12-01 Last updated: 2024-03-19Bibliographically approved

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Vallin, Karl Schipper, Nicolaas

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v. 2.45.0

WCAG

Warpman Berglund, U.

Sanjiv, K.

Gad, H.

Kalderén, C.

Koolmeister, T.

Pham, T.

Gokturk, C.

Jafari, R.

G., Maddalo

Seashore-Ludlow, B.

Chernobrovkin, A.

Manoilov, A.

Pateras, I. S.

Rasti, A.

Jemth, A.-S.

Almlöf, I.

Loseva, O.

Visnes, T.

Einarsdottir, B. O.

Gaugaz, F. Z.

Saleh, A.

Platzack, B.

Wallner, O. A.

Vallin, Karl

Henriksson, M.

Wakchaure, P.

Borhade, S.

Herr, P.

Kallberg, Y.

Baranczewski, P.

Homan, E. J.

Wiita, E.

Nagpal, V.

Meijer, T.

Schipper, Nicolaas

Rudd, S. D.

Bräutigam, L.

Lindqvist, A.

Filppula, A.

Lee, T-C.

Artursson, P.

Nilsson, J. A.

Gorgoulis, V. G.

Lehtiö, J.

Zubarev, R. A.

Scobie, M.

Helleday, T.

Abstract [en]

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