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Producing ultrapure wood cellulose nanofibrils and evaluating the cytotoxicity using human skin cells
RISE, Innventia, PFI – Paper and Fiber Research Institute.ORCID iD: 0000-0002-6183-2017
2016 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 150, 65-73 p.Article in journal (Refereed) Published
Abstract [en]

Wood cellulose nanofibrils (CNF) have been suggested as a potential wound healing material, but its utilization is limited by FDA requirements regarding endotoxin levels. In this study a method using sodium hydroxide followed by TEMPO mediated oxidation was developed to produce ultrapure cellulose nanofibrils, with an endotoxin level of 45 endotoxin units/g (EU/g) cellulose. Scanning transmission electron microscopy (S(T)EM) revealed a highly nanofibrillated structure (lateral width of 3.7 ± 1.3 nm). Assessment of cytotoxicity and metabolic activity on Normal Human Dermal Fibroblasts and Human Epidermal Keratinocytes was done. CNF-dispersion of 50 ÎŒg/ml did not affect the cells. CNF-aerogels induced a reduction of metabolic activity by the fibroblasts and keratinocytes, but no significant cell death. Cytokine profiling revealed no induction of the 27 cytokines tested upon exposure to CNF. The moisture-holding capacity of aerogels was relatively high (∌7500%), compared to a commercially available wound dressing (∌2500%), indicating that the CNF material is promising as dressing material for management of wounds with a moderate to high amount of exudate. .

Place, publisher, year, edition, pages
2016. Vol. 150, 65-73 p.
National Category
Biomaterials Science Nano Technology
Identifiers
URN: urn:nbn:se:ri:diva-18920DOI: 10.1016/j.carbpol.2016.04.094Scopus ID: 2-s2.0-84969753338OAI: oai:DiVA.org:ri-18920DiVA: diva2:1040156
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cited By 0

Available from: 2016-10-26 Created: 2016-10-26 Last updated: 2016-10-26Bibliographically approved

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CiteExportLink to record
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