In this paper, a series of experimental bending and compression tests were performed on cross-laminated timber (CLT) products with ±45° alternating layers, to evaluate their performance against conventional panels of 90° orientation. Engineered wood products, such as CLT with ±45° alternating layers can provide opportunities for greater use in larger and more sustainable timber constructions. A total of 40 panels, manufactured in an industrial CLT production line with either of these two configurations, were tested and compared. Panels were evaluated in bending tests n=20 and the remaining ones in compression tests. Results showed that 35% increased the strength in the fourpoint bending tests for panels containing ±45° alternating layers compared with the 90° alternating layers. Compression strength was increased by 15%. Stiffness increased by 15% in the four-point bending and 30% in the compression. The results indicate that CLT containing ±45° alternating layers has increased strength and stiffness compared to 90° alternating layers. These findings suggest that further developments in CLT are feasible in advanced building applications.