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Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro
The New York Stem Cell Foundation Research Institute, USA; Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
Sahlgrenska Academy, Sweden; BIOMATCELL, Sweden.
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2014 (English)In: International Journal of Nanomedicine, ISSN 1176-9114, E-ISSN 1178-2013, Vol. 9, no 1, p. 2499-2515Article in journal (Refereed) Published
Abstract [en]

Background: Patterning medical devices at the nanoscale level enables the manipulation of cell behavior and tissue regeneration, with topographic features recognized as playing a significant role inthe osseointegration of implantable devices. Methods: In this study, we assessed the ability of titanium-coated hemisphere-like topographic nanostructures of different sizes (approximately 50, 100, and 200 nm) to influence the morphology, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs). Results: We found that the proliferation and osteogenicdifferentiation of hMSCs was influenced by the size of the underlying structures, suggesting that size variations in topographic features at the nanoscale level, independently of chemistry, can be exploited to control hMSC behavior in a size-dependent fashion. Conclusion: Our studies demonstrate that colloidal lithography, in combination with coating technologies, can be exploited to investigate the cell response to well defined nanoscale topography and to develop next-generation surfaces that guide tissue regeneration and promote implant integration.

Place, publisher, year, edition, pages
2014. Vol. 9, no 1, p. 2499-2515
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Natural Sciences
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URN: urn:nbn:se:ri:diva-6740DOI: 10.2147/IJN.S58805Scopus ID: 2-s2.0-84901424254Local ID: 23761OAI: oai:DiVA.org:ri-6740DiVA, id: diva2:964580
Available from: 2016-09-08 Created: 2016-09-08 Last updated: 2023-06-07Bibliographically approved

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Sjövall, PeterLausmaa, JukkaPetronis, Sarunas

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