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Efficacy of the novel topical antimicrobial agent pxl150 in a mouse model of surgical site infections
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.ORCID iD: 0000-0002-4270-8475
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.
2014 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 58, no 5, p. 2982-2984Article in journal (Refereed) Published
Abstract [en]

Antimicrobial peptides have recently emerged as a promising new group to be evaluated in the therapeutic intervention of infectious diseases. This study evaluated the anti-infectious effect of the short, synthetic, broad-spectrum antimicrobial peptide PXL150 in a mouse model of staphylococcal surgical site infections. We found that administration of PXL150, formulated in an aqueous solution or in a hydroxypropyl cellulose gel, significantly reduced the bacterial counts in the wound compared with placebo treatment, warranting further investigations of the potential of this peptide as a novel local treatment of microbial infections.

Place, publisher, year, edition, pages
2014. Vol. 58, no 5, p. 2982-2984
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Natural Sciences
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URN: urn:nbn:se:ri:diva-6731DOI: 10.1128/AAC.00143-14Scopus ID: 2-s2.0-84898639878Local ID: 23742OAI: oai:DiVA.org:ri-6731DiVA, id: diva2:964571
Available from: 2016-09-08 Created: 2016-09-08 Last updated: 2019-08-12Bibliographically approved

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Håkansson, Joakim

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