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Development of a grignard-type reaction for manufacturing in a continuous-flow reactor
RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Process Development, Processutveckling och kristallisation. AstraZeneca, Sweden.
RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Process Development, Processutveckling och kristallisation. AstraZeneca, Sweden.
AstraZeneca, Sweden.
2014 (engelsk)Inngår i: International journal of thermophysics, ISSN 0195-928X, E-ISSN 1572-9567, Vol. 18, nr 11, s. 1545-1549Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

This paper describes the scale-up of a highly exothermic and fast reaction from a microreactor with an internal volume of less than 1 mL to a mesoreactor with an internal volume of 13.5 mL. The development of a continuous process for manufacturing a ketone from an ester using a Grignard reagent is described. The different steps undertaken and the considerations made to be able to operate in continuous mode and achieve a product output of ca. 0.5 kg are presented.

sted, utgiver, år, opplag, sider
2014. Vol. 18, nr 11, s. 1545-1549
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URN: urn:nbn:se:ri:diva-6702DOI: 10.1021/op500290xScopus ID: 2-s2.0-84913535090Lokal ID: 23697OAI: oai:DiVA.org:ri-6702DiVA, id: diva2:964542
Tilgjengelig fra: 2016-09-08 Laget: 2016-09-08 Sist oppdatert: 2020-12-01bibliografisk kontrollert

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