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Development of a grignard-type reaction for manufacturing in a continuous-flow reactor
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Process Development, Processutveckling och kristallisation. AstraZeneca, Sweden.
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Process Development, Processutveckling och kristallisation. AstraZeneca, Sweden.
AstraZeneca, Sweden.
2014 (English)In: International journal of thermophysics, ISSN 0195-928X, E-ISSN 1572-9567, Vol. 18, no 11, p. 1545-1549Article in journal (Refereed) Published
Abstract [en]

This paper describes the scale-up of a highly exothermic and fast reaction from a microreactor with an internal volume of less than 1 mL to a mesoreactor with an internal volume of 13.5 mL. The development of a continuous process for manufacturing a ketone from an ester using a Grignard reagent is described. The different steps undertaken and the considerations made to be able to operate in continuous mode and achieve a product output of ca. 0.5 kg are presented.

Place, publisher, year, edition, pages
2014. Vol. 18, no 11, p. 1545-1549
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-6702DOI: 10.1021/op500290xScopus ID: 2-s2.0-84913535090Local ID: 23697OAI: oai:DiVA.org:ri-6702DiVA, id: diva2:964542
Available from: 2016-09-08 Created: 2016-09-08 Last updated: 2020-12-01Bibliographically approved

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