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Osseointegration of titanium with an antimicrobial nanostructured noble metal coating
BIOMATCELL, Sweden; Sahlgrenska Academy, Sweden.
BIOMATCELL, Sweden; Sahlgrenska Academy, Sweden.
BIOMATCELL, Sweden; Sahlgrenska Academy, Sweden.
BIOMATCELL, Sweden; Sahlgrenska Academy, Sweden.
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2013 (English)In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 9, no 7, p. 1048-1056Article in journal (Refereed) Published
Abstract [en]

Nanometer scale surface features on implants and prostheses can potentially be used to enhance osseointegration and may also add further functionalities, such as infection resistance, to the implant. In this study, a nanostructured noble metal coating consisting of palladium, gold and silver, never previously used in bone applications, was applied to machined titanium screws to evaluate osseointegration after 6 and 12. weeks in rabbit tibiae and femurs. Infection resistance was confirmed by in vitro adhesion test. A qualitatively and quantitatively similar in vivo bone response was observed for the coated and uncoated control screws, using histology, histomorphometry and electron microscopy. The bone-implant interface analysis revealed an extensive bone formation and direct bone-implant contact. These results demonstrate that the nanostructured noble metal coating with antimicrobial properties promotes osseointegration and may therefore be used to add extra implant functionality in the form of increased resistance to infection without the use of antibiotics. From the Clinical Editor: The authors of this paper demonstrate that nanostructured noble metal coating of implants and prostheses used in orthopedic procedures promotes osseointegration and may be used to add extra implant functionality in the form of increased resistance to infection without the use of antibiotics.

Place, publisher, year, edition, pages
2013. Vol. 9, no 7, p. 1048-1056
Keywords [en]
Antimicrobial, Nanotopography, Noble metals, Osseointegration, Titanium
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-6533DOI: 10.1016/j.nano.2013.04.009Scopus ID: 2-s2.0-84884287103Local ID: 23811OAI: oai:DiVA.org:ri-6533DiVA, id: diva2:964371
Available from: 2016-09-08 Created: 2016-09-08 Last updated: 2024-05-21Bibliographically approved

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Lyvén, BennyLausmaa, Jukka

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SP – Sveriges Tekniska ForskningsinstitutSP – Sveriges Tekniska Forskningsinstitut / Funktionella material (KMf)
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