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Keeping it real: The importance of material characterization in nanotoxicology
Karolinska Institute, Sweden.
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Material och ytteknik.
KTH Royal Institute of Technology, Sweden.
Karolinska Institute, Sweden.
2015 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 468, no 3, p. 498-503Article, review/survey (Refereed) Published
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Text
Abstract [en]

Nanomaterials are small and the small size and corresponding large surface area of nanomaterials confers specific properties, making these materials desirable for various applications, not least in medicine. However, it is pertinent to ask whether size is the only property that matters for the desirable or detrimental effects of nanomaterials? Indeed, it is important to know not only what the material looks like, but also what it is made of, as well as how the material interacts with its biological surroundings. It has been suggested that guidelines should be implemented on the types of information required in terms of physicochemical characterization of nanomaterials for toxicological studies in order to improve the quality and relevance of the published results. This is certainly a key issue, but it is important to keep in mind that material characterization should be fit-for-purpose, that is, the information gathered should be relevant for the end-points being studied.

Place, publisher, year, edition, pages
2015. Vol. 468, no 3, p. 498-503
Keywords [en]
bio-corona, engineered nanomaterials, nanotoxicology, physicochemical characterization
National Category
Nano Technology Biophysics Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:ri:diva-148DOI: 10.1016/j.bbrc.2015.06.178Scopus ID: 2-s2.0-84951568750OAI: oai:DiVA.org:ri-148DiVA, id: diva2:939306
Note

Publication no: A3567

Available from: 2016-06-18 Created: 2016-06-07 Last updated: 2020-12-01Bibliographically approved

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