Recent experiments have shown that exposed cross-laminated timber (CLT) can have a significant effect on the fire dynamics of large compartments. A simulation with the Fire Dynamic Simulator has been conducted to better understand the fire behaviour of open-plan compartments with exposed CLT. The simulation was set up to replicate a large-scale experiment, FRIC-02, with exposed CLT on the back wall and ceiling. The compartment was 95 m2 (18.8 m × 5.0 m × 2.5 m), with one long wall open (opening factor 0.18 m1/2). A continuous wood crib was used as the variable fuel load. The characteristic results of FRIC-02 with a rapid fire development and non-symmetrical external flames were successfully reproduced. With the wind coming diagonally from behind, as in FRIC-02, the external flames emerged mainly out of one window. The flames covered the entire window height, which effectively inhibited the inflow of air through that window. The imbalance in air supply also created large temperature differences throughout the compartment. With no implementation of wind, external flames and temperatures were more symmetrical. Despite a good match to FRIC-02, the method still has several limitations, including the adaption of the burning rate to the feedback from surroundings.