The use of external fire suppression systems can reduce the risk of fire spreading between buildings. This study investigated the effectiveness and efficiency of different externally placed water-based fire suppression systems on façade fire safety. A series of large-scale experiments comprising an SP Fire 105 setup equipped with sprinklers and high-pressure water mist nozzles have been performed. A combustible facade, consisting of 2.5 cm thick oriented strand board (OSB) plates, was installed to provide challenging conditions and allow a visual assessment of the post-fire damage. The temperature profile on the façade surface was measured with 34 thermocouples, while five heat flux gauges and two fast-response plate thermocouples were used to measure the heat flux on the facade surface and emitted to the ambient. The sprinklers and the high-pressure water mist system effectively suppressed the upwards flame migration and reduced the heat flux toward adjacent buildings. It was observed that the sprinklers acted as a water curtain and kept the facade wet during the fire, promoting minor damage (the burnt area is less than 1% of the total area). The temperature and heat flux measurements demonstrated that the sprinkler system was the most effective suppression system. However, the high-pressure water mist systems achieved similar effectiveness but a much higher efficiency concerning water consumption. The sprinkler nozzles used four times as much water as the high-pressure water mist nozzles.