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Flexible and Biocompatible Antifouling Polyurethane Surfaces Incorporating Tethered Antimicrobial Peptides through Click Reactions
RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology. University of Gothenburg, Sweden.ORCID iD: 0000-0002-9377-8924
Amicoat A/S, Norway; UiT The Arctic University of Norway, Norway.
RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology.
Amicoat A/S, Norway.
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2023 (English)In: Macromolecular Bioscience, ISSN 1616-5187, E-ISSN 1616-5195Article in journal (Refereed) Epub ahead of print
Abstract [en]

Efficient, simple antibacterial materials to combat implant-associated infections are much in demand. Herein, the development of polyurethanes, both cross-linked thermoset and flexible and versatile thermoplastic, suitable for “click on demand” attachment of antibacterial compounds enabled via incorporation of an alkyne-containing diol monomer in the polymer backbone, is described. By employing different polyolic polytetrahydrofurans, isocyanates, and chain extenders, a robust and flexible material comparable to commercial thermoplastic polyurethane is prepared. A series of short synthetic antimicrobial peptides are designed, synthesized, and covalently attached in a single coupling step to generate a homogenous coating. The lead material is shown to be biocompatible and does not display any toxicity against either mouse fibroblasts or reconstructed human epidermis according to ISO and OECD guidelines. The repelling performance of the peptide-coated materials is illustrated against colonization and biofilm formation by Staphylococcus aureus and Staphylococcus epidermidis on coated plastic films and finally, on coated commercial central venous catheters employing LIVE/DEAD staining, confocal laser scanning microscopy, and bacterial counts. This study presents the successful development of a versatile and scalable polyurethane with the potential for use in the medical field to reduce the impact of bacterial biofilms. 

Place, publisher, year, edition, pages
John Wiley and Sons Inc , 2023.
Keywords [en]
Bacteria; Biocompatibility; Biofilms; Cell culture; Coated materials; Crosslinking; Peptides; Plastic coatings; Reinforced plastics; Anti-foulings; Antibacterial materials; Antimicrobial peptide; Biocompatible; Click chemistry; Click reaction; Flexible; Implant-associated infection; On demands; Simple++; Polyurethanes
National Category
Polymer Chemistry Biomaterials Science Polymer Technologies
Identifiers
URN: urn:nbn:se:ri:diva-68814DOI: 10.1002/mabi.202300425Scopus ID: 2-s2.0-85178409798OAI: oai:DiVA.org:ri-68814DiVA, id: diva2:1825023
Note

This study was financed by Amicoat A/S. The authors are grateful for the analytical assistance from RISE scientists L. Brive, P. Borchardt, K. Johansson, and J. Somertune.

Available from: 2024-01-08 Created: 2024-01-08 Last updated: 2024-01-15Bibliographically approved

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Berglin, MattiasSvenson, Johan

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