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Polyanhydride Microcapsules Exhibiting a Sharp pH Transition at Physiological Conditions for Instantaneous Triggered Release
Chalmers university of Technology, Sweden.
Chalmers university of Technology, Sweden.
Chalmers university of Technology, Sweden.
RISE Research Institutes of Sweden, Materials and Production, Polymeric Materials and Composites.ORCID iD: 0000-0002-7939-4684
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2023 (English)In: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 39, no 49, p. 18003-18010Article in journal (Refereed) Published
Abstract [en]

Stimulus-responsive microcapsules pose an opportunity to achieve controlled release of the entire load instantaneously upon exposure to an external stimulus. Core-shell microcapsules based on the polyanhydride poly(bis(2-carboxyphenyl)adipate) as a shell were formulated in this work to encapsulate the model active substance pyrene and enable a pH-controlled triggered release. A remarkably narrow triggering pH interval was found where a change in pH from 6.4 to 6.9 allowed for release of the entire core content within seconds. The degradation kinetics of the shell were measured by both spectrophotometric detection of degradation products and mass changes by quartz crystal microbalance with dissipation monitoring and were found to correlate excellently with diffusion coefficients fitted to release measurements at varying pH values. The microcapsules presented in this work allow for an almost instantaneous triggered release even under mild conditions, thanks to the designed core-shell morphology. 

Place, publisher, year, edition, pages
American Chemical Society , 2023. Vol. 39, no 49, p. 18003-18010
Keywords [en]
Degradation; Microstructure; adipic acid; polyanhydride; pyrene; Active substance; Adipates; Controlled release; Core-shell microcapsules; External stimulus; Microcapsules; Physiological condition; Polyanhydrides; Stimuli-responsive; Triggered release; article; controlled study; degradation; degradation kinetics; diffusion coefficient; microcapsule; pH; quartz crystal microbalance; spectrophotometry; Shells (structures)
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:ri:diva-68823DOI: 10.1021/acs.langmuir.3c02708Scopus ID: 2-s2.0-85178628994OAI: oai:DiVA.org:ri-68823DiVA, id: diva2:1824969
Funder
Swedish Research Council Formas, 2018-02284
Note

The Swedish Research Council FORMAS (2018-02284) is acknowledged for funding. The authors would like to thank Sofie Ekström, Ellen Emanuelsson, Sebastian Ladisic, and Emma Pettersson for their contributions to the laboratory work.

Available from: 2024-01-08 Created: 2024-01-08 Last updated: 2024-01-10Bibliographically approved

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Andersson Trojer, Markus

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