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Biocomposites containing poly(lactic acid) and chitosan for 3D printing: Assessment of mechanical, antibacterial and in vitro biodegradability properties
Swiss Federal Institute of Technology Zurich, Switzerland.
RISE Research Institutes of Sweden, Bioeconomy and Health, Material and Surface Design.ORCID iD: 0000-0003-1779-9923
RISE Research Institutes of Sweden, Bioeconomy and Health, Material and Surface Design.ORCID iD: 0000-0001-7658-9091
RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology.ORCID iD: 0009-0004-4933-6629
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2023 (English)In: Journal of The Mechanical Behavior of Biomedical Materials, ISSN 1751-6161, E-ISSN 1878-0180, Vol. 147, article id 106136Article in journal (Refereed) Published
Abstract [en]

New bone repair materials are needed for treatment of trauma- and disease-related skeletal defects as they still represent a major challenge in clinical practice. Additionally, new strategies are required to combat orthopedic device-related infections (ODRI), given the rising incidence of total joint replacement and fracture fixation surgeries in increasingly elderly populations. Recently, the convergence of additive manufacturing (AM) and bone tissue engineering (BTE) has facilitated the development of bone healthcare to achieve personalized three-dimensional (3D) scaffolds. This study focused on the development of a 3D printable bone repair material, based on the biopolymers poly(lactic acid) (PLA) and chitosan. Two different types of PLA and chitosan differing in their molecular weight (MW) were explored. The novel feature of this research was the successful 3D printing using biocomposite filaments composed of PLA and 10 wt% chitosan, with clear chitosan entrapment within the PLA matrix confirmed by Scanning Electron Microscopy (SEM) images. Tensile testing of injection molded samples indicated an increase in stiffness, compared to pure PLA scaffolds, suggesting potential for improved load-bearing characteristics in bone scaffolds. However, the potential benefit of chitosan on the biocomposite stiffness could not be reproduced in compression testing of 3D printed cylinders. The antibacterial assays confirmed antibacterial activity of chitosan when dissolved in acetic acid. The study also verified the biodegradability of the scaffolds, with a process producing an acidic environment that could potentially be neutralized by chitosan. In conclusion, the study indicated the feasibility of the proposed PLA/chitosan biocomposite for 3D printing, demonstrating adequate mechanical strength, antibacterial properties and biodegradability, which could serve as a new material for bone repair.

Place, publisher, year, edition, pages
Elsevier Ltd , 2023. Vol. 147, article id 106136
Keywords [en]
3D printing; Biodegradability; Biopolymers; Compression testing; Injection molding; Lactic acid; Repair; Scaffolds (biology); Scanning electron microscopy; Stiffness; Stiffness matrix; Tensile testing; 3-D printing; 3D-printing; Antibacterials; Biocomposite; Bone repair materials; In-vitro; Mechanical; Poly lactic acid; Poly(lactic acid); Property; Chitosan
National Category
Polymer Technologies
Identifiers
URN: urn:nbn:se:ri:diva-67723DOI: 10.1016/j.jmbbm.2023.106136Scopus ID: 2-s2.0-85172305781OAI: oai:DiVA.org:ri-67723DiVA, id: diva2:1809511
Funder
The Research Council of Norway, 337610
Note

Norges forskningsråd

Available from: 2023-11-03 Created: 2023-11-03 Last updated: 2023-11-21Bibliographically approved

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Pasquier, EvaSolberg, AmalieAgrenius, KarinHåkansson, JoakimChinga Carrasco, Gary

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