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Controlling the structure of spin-coated multilayer ethylcellulose/hydroxypropylcellulose films for drug release.
RISE Research Institutes of Sweden, Bioeconomy and Health, Agriculture and Food. Chalmers University of Technology, Sweden.
Wendelsbergs beräkningskemi AB, Sweden.
Wendelsbergs beräkningskemi AB, Sweden.
RISE Research Institutes of Sweden, Bioeconomy and Health, Agriculture and Food.ORCID iD: 0000-0003-1258-4448
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2023 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 644, article id 123350Article in journal (Refereed) Published
Abstract [en]

Porous phase-separated ethylcellulose/hydroxypropylcellulose (EC/HPC) films are used to control drug transport out of pharmaceutical pellets. Water-soluble HPC leaches out and forms a porous structure that controls the drug transport. Industrially, the pellets are coated using a fluidized bed spraying device, and a layered film exhibiting varying porosity and structure after leaching is obtained. A detailed understanding of the formation of the multilayered, phase-separated structure during production is lacking. Here, we have investigated multilayered EC/HPC films produced by sequential spin-coating, which was used to mimic the industrial process. The effects of EC/HPC ratio and spin speed on the multilayer film formation and structure were investigated using advanced microscopy techniques and image analysis. Cahn-Hilliard simulations were performed to analyze the mixing behavior. A gradient with larger structures close to the substrate surface and smaller structures close to the air surface was formed due to coarsening of the layers already coated during successive deposition cycles. The porosity of the multilayer film was found to vary with both EC/HPC ratio and spin speed. Simulation of the mixing behavior and in situ characterization of the structure evolution showed that the origin of the discontinuities and multilayer structure can be explained by the non-mixing of the layers.

Place, publisher, year, edition, pages
2023. Vol. 644, article id 123350
Keywords [en]
Cahn-Hilliard simulations, cellulose, confocal laser scanning microscope, electron microscopy, multilayer film, phase separation kinetics, phase separation mechanisms, porous film for controlled release
National Category
Food Science
Identifiers
URN: urn:nbn:se:ri:diva-66152DOI: 10.1016/j.ijpharm.2023.123350PubMedID: 37640089OAI: oai:DiVA.org:ri-66152DiVA, id: diva2:1795420
Note

The Swedish Foundation for Strategic Research (SSF grant FID16-0013), the Swedish Research Council (VR grant 2018-03986), and the Swedish Research Council for Sustainable Development (grant 2019-01295) are gratefully acknowledged for the funding. AstraZeneca is acknowledged for the financial support and materials. Funding is acknowledged by the Fund for Scientific Research Flanders (grants I012020N & I000321N) and the Special Research Fund of Ghent University (grant BOF.COR.2022.0003.01). 

Available from: 2023-09-08 Created: 2023-09-08 Last updated: 2024-06-10Bibliographically approved

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Nilsson Pingel, TorbenRöding, MagnusLoren, Niklas

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