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Development of an All-Marine 3D Printed Bioactive Hydrogel Dressing for Treatment of Hard-to-Heal Wounds
RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology.ORCID iD: 0000-0002-9442-7245
RISE Research Institutes of Sweden, Bioeconomy and Health, Chemical Process and Pharmaceutical Development.ORCID iD: 0000-0001-7596-5075
Regenics AS, Norway.
RISE Research Institutes of Sweden, Materials and Production, Chemistry, Biomaterials and Textiles.
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2023 (English)In: Polymers, E-ISSN 2073-4360, Vol. 15, no 12, article id 2627Article in journal (Refereed) Published
Abstract [en]

Current standard wound care involves dressings that provide moisture and protection; however, dressings providing active healing are still scarce and expensive. We aimed to develop an ecologically sustainable 3D printed bioactive hydrogel-based topical wound dressing targeting healing of hard-to-heal wounds, such as chronic or burn wounds, which are low on exudate. To this end, we developed a formulation composed of renewable marine components; purified extract from unfertilized salmon roe (heat-treated X, HTX), alginate from brown seaweed, and nanocellulose from tunicates. HTX is believed to facilitate the wound healing process. The components were successfully formulated into a 3D printable ink that was used to create a hydrogel lattice structure. The 3D printed hydrogel showed a HTX release profile enhancing pro-collagen I alpha 1 production in cell culture with potential of promoting wound closure rates. The dressing has recently been tested on burn wounds in Göttingen minipigs and shows accelerated wound closure and reduced inflammation. This paper describes the dressings development, mechanical properties, bioactivity, and safety. 

Place, publisher, year, edition, pages
MDPI , 2023. Vol. 15, no 12, article id 2627
Keywords [en]
3D printed scaffolds, alginate, biomaterial, hard-to-heal wounds, nanocellulose, salmon roe, wound dressing, 3D printing, Biomechanics, Cell culture, Hydrogels, %moisture, 'current, 3d printed scaffold, Bioactive hydrogels, Hard-to-heal wound, Hydrogels dressings, Nano-cellulose, Wound closure, Wound dressings
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:ri:diva-65731DOI: 10.3390/polym15122627Scopus ID: 2-s2.0-85163772755OAI: oai:DiVA.org:ri-65731DiVA, id: diva2:1786265
Note

Correspondence Address: P. Stenlund; Department of Methodology, Textile and Medical Technology, RISE Research Institutes of Sweden AB, Gothenburg, Arvid Wallgrens backe 20, SE-413 46, Sweden;  This research was funded by ERA-Net Cofund on the Blue Bioeconomy—Unlocking the Potential of Aquatic Bioresources (BlueBio ID: 151), Swedish Research Council for Environment Agricultural Sciences and Spatial Planning (2019-02350), and Norwegian Research Council (311702).

Available from: 2023-08-08 Created: 2023-08-08 Last updated: 2024-04-02Bibliographically approved

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Stenlund, PatrikEnstedt, LinneaAhlinder, AstridLundin Johnson, MariaMillqvist-Fureby, AnnaBerglin, Mattias

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Product Realisation MethodologyChemical Process and Pharmaceutical DevelopmentChemistry, Biomaterials and TextilesAgriculture and FoodRISE Research Institutes of Sweden
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