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Polysaccharides and Structural Proteins as Components in Three-Dimensional Scaffolds for Breast Cancer Tissue Models: A Review
RISE Research Institutes of Sweden, Bioeconomy and Health, Material and Surface Design.ORCID iD: 0000-0003-1779-9923
RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology.ORCID iD: 0000-0002-8849-1793
RISE Research Institutes of Sweden, Bioeconomy and Health, Material and Surface Design.ORCID iD: 0000-0001-7658-9091
University of Gothenburg, Sweden; Sahlgrenska University Hospital, Sweden.
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2023 (English)In: Bioengineering, E-ISSN 2306-5354, Vol. 10, no 6, article id 682Article in journal (Refereed) Published
Abstract [en]

Breast cancer is the most common cancer among women, and even though treatments are available, efficiency varies with the patients. In vitro 2D models are commonly used to develop new treatments. However, 2D models overestimate drug efficiency, which increases the failure rate in later phase III clinical trials. New model systems that allow extensive and efficient drug screening are thus required. Three-dimensional printed hydrogels containing active components for cancer cell growth are interesting candidates for the preparation of next generation cancer cell models. Macromolecules, obtained from marine- and land-based resources, can form biopolymers (polysaccharides such as alginate, chitosan, hyaluronic acid, and cellulose) and bioactive components (structural proteins such as collagen, gelatin, and silk fibroin) in hydrogels with adequate physical properties in terms of porosity, rheology, and mechanical strength. Hence, in this study attention is given to biofabrication methods and to the modification with biological macromolecules to become bioactive and, thus, optimize 3D printed structures that better mimic the cancer cell microenvironment. Ink formulations combining polysaccharides for tuning the mechanical properties and bioactive polymers for controlling cell adhesion is key to optimizing the growth of the cancer cells. © 2023 by the authors.

Place, publisher, year, edition, pages
MDPI , 2023. Vol. 10, no 6, article id 682
Keywords [en]
3D bioprinting, biopolymers, breast cancer models, cells microenvironment
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:ri:diva-65684DOI: 10.3390/bioengineering10060682Scopus ID: 2-s2.0-85163723963OAI: oai:DiVA.org:ri-65684DiVA, id: diva2:1786115
Note

Correspondence Address: G. Chinga-Carrasco; RISE PFI AS, Trondheim, Høgskoleringen 6b, NO-7491, Norway; E.P.: A.S. (Amalie Solberg), and G.C.-C. thank the Research Council of Norway and bioMAT4EYE project (Grant 337610) for funding part of this work. A.S. (Anders Ståhlberg) is funded by Region Västra Götaland, Swedish Cancer Society (2022-2080), Swedish Childhood Cancer Foundation (2022-0030), Swedish Research Council (2021-01008); the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement (965065), Sweden’s Innovation Agency and the Sjöberg Foundation. J.H. and J.R. are funded by the Swedish Foundation for Strategic Research (FID15-0008), Sweden’s Innovation Agency (2017-03737 and 2021-04484) and Region Västra Götalandsregionen (RUN 2018-00017).

Available from: 2023-08-07 Created: 2023-08-07 Last updated: 2023-11-03Bibliographically approved

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Pasquier, EvaRosendahl, JenniferSolberg, AmalieHåkansson, JoakimChinga Carrasco, Gary

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