An explorative study on respiratory health among operators working in polymer additive manufacturingShow others and affiliations
2023 (English)In: Frontiers in Public Health, E-ISSN 2296-2565, Vol. 11, article id 1148974Article in journal (Refereed) Published
Abstract [en]
Additive manufacturing (AM), or 3D printing, is a growing industry involving a wide range of different techniques and materials. The potential toxicological effects of emissions produced in the process, involving both ultrafine particles and volatile organic compounds (VOCs), are unclear, and there are concerns regarding possible health implications among AM operators. The objective of this study was to screen the presence of respiratory health effects among people working with liquid, powdered, or filament plastic materials in AM. Methods: In total, 18 subjects working with different additive manufacturing techniques and production of filament with polymer feedstock and 20 controls participated in the study. Study subjects filled out a questionnaire and underwent blood and urine sampling, spirometry, impulse oscillometry (IOS), exhaled NO test (FeNO), and collection of particles in exhaled air (PEx), and the exposure was assessed. Analysis of exhaled particles included lung surfactant components such as surfactant protein A (SP-A) and phosphatidylcholines. SP-A and albumin were determined using ELISA. Using reversed-phase liquid chromatography and targeted mass spectrometry, the relative abundance of 15 species of phosphatidylcholine (PC) was determined in exhaled particles. The results were evaluated by univariate and multivariate statistical analyses (principal component analysis). Results: Exposure and emission measurements in AM settings revealed a large variation in particle and VOC concentrations as well as the composition of VOCs, depending on the AM technique and feedstock. Levels of FeNO, IOS, and spirometry parameters were within clinical reference values for all AM operators. There was a difference in the relative abundance of saturated, notably dipalmitoylphosphatidylcholine (PC16:0_16:0), and unsaturated lung surfactant lipids in exhaled particles between controls and AM operators. Conclusion: There were no statistically significant differences between AM operators and controls for the different health examinations, which may be due to the low number of participants. However, the observed difference in the PC lipid profile in exhaled particles indicates a possible impact of the exposure and could be used as possible early biomarkers of adverse effects in the airways.
Place, publisher, year, edition, pages
Frontiers Media S.A. , 2023. Vol. 11, article id 1148974
Keywords [en]
additive manufacturing, exhaled air, exposure, lung surfactant, nanoparticles, phosphatidylcholine
National Category
Occupational Health and Environmental Health Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:ri:diva-64852DOI: 10.3389/fpubh.2023.1148974Scopus ID: 2-s2.0-85158004051OAI: oai:DiVA.org:ri-64852DiVA, id: diva2:1758132
Funder
Vinnova, 2018-03336Forte, Swedish Research Council for Health, Working Life and Welfare, 2018-00290
Note
The study was funded by a grant from the Swedish Innovation Agency (Vinnova), HÄMAT2 (dnr 2018-03336), and the Swedish Research Council for Health, Working Life and Welfare (Forte) (dnr 2018-00290).
2023-05-222023-05-222024-09-04Bibliographically approved