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In-line measurements of the physical and thermodynamic properties of single and multicomponent liquids
NQIS/EIM Sindos, Greece.
RISE Research Institutes of Sweden, Safety and Transport, Measurement Technology.ORCID iD: 0000-0001-5118-0150
RISE Research Institutes of Sweden, Safety and Transport, Measurement Technology.
TUV SUD National Engineering Laboratory, UK.
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2023 (English)In: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 68, no 1, p. 39-50Article in journal (Refereed) Published
Abstract [en]

Microfluidic devices are becoming increasingly important in various fields of pharmacy, flow chemistry and healthcare. In the embedded microchannel, the flow rates, the dynamic viscosity of the transported liquids and the fluid dynamic properties play an important role. Various functional auxiliary components of microfluidic devices such as flow restrictors, valves and flow meters need to be characterised with liquids used in several microfluidic applications. However, calibration with water does not always reflect the behaviour of the liquids used in the different applications. Therefore, several National Metrology Institutes (NMI) have developed micro-pipe viscometers for traceable inline measurement of the dynamic viscosity of liquids used in flow applications as part of the EMPIR 18HLT08 MeDDII project. These micro-pipe viscometers allow the calibration of any flow device at different flow rates and the calibration of the dynamic viscosity of the liquid or liquid mixture used under actual flow conditions. The validation of the micro-pipe viscometers has been performed either with traceable reference oils or with different liquids typically administered in hospitals, such as saline and/or glucose solutions or even glycerol-water mixtures for higher dynamic viscosities. Furthermore, measurement results of a commercially available device and a technology demonstrator for the inline measurement of dynamic viscosity and density are presented in this paper. © 2022 the author(s)

Place, publisher, year, edition, pages
De Gruyter Open Ltd , 2023. Vol. 68, no 1, p. 39-50
Keywords [en]
calibration, dynamic viscosity, micro-pipe viscometer, traceability, Flow rate, Flowmeters, Fluidic devices, Liquids, Microfluidics, Saline water, Thermodynamic properties, Viscometers, Viscosity, Viscosity measurement, Dynamic viscosities, Embedded microchannels, Flow chemistry, In-line measurements, Measurements of, Microfluidics devices, Multicomponent liquids, Thermodynamics property
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:ri:diva-61423DOI: 10.1515/bmt-2022-0039Scopus ID: 2-s2.0-85142069917OAI: oai:DiVA.org:ri-61423DiVA, id: diva2:1717209
Note

Funding details: Horizon 2020 Framework Programme, H2020; Funding details: European Metrology Programme for Innovation and Research, EMPIR; Funding text 1: Research funding: This project 18HLT08 MEDDII has received funding from the EMPIR programme co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation programme.

Available from: 2022-12-07 Created: 2022-12-07 Last updated: 2023-12-20Bibliographically approved

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Büker, Oliver

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